Photodynamic action refers to the function or morphological change of organism cells or biomolecules under the action of photosensitizers under the action of light. In severe cases, it causes cell damage and necrosis. This action must be participated by oxygen. It is called photosensitization-oxidation, which is chemically called photosensitization. It is called photodynamic action in biology and medicine.
The method of treating diseases with photodynamic action is called photodynamic therapy (PDT). Photodynamic therapy is a new disease treatment method based on the interaction of light, photosensitizers and oxygen. The study of photosensitizers (photodynamic therapy drugs) is the key to affecting the prospect of photodynamic therapy. Photosensitizers are some special chemical substances.
Their basic function is to transfer energy. They can be excited by absorbing photons, and quickly transfer the absorbed light energy to the molecules of another component, causing them to be excited and the photosensitizer itself to return. Ground state. With the first photosensitizer PorfimerSodium being approved for marketing in the United States, Canada, the European Union, Japan, and South Korea from 1993 to 1997, research, development, and application in the PDT field have become rapidly active.
In recent years, with the successful development of new photodynamic therapeutic drugs and the improvement of laser equipment technology, PDT has ushered in an unprecedented peak of development. Internationally, nearly ten new photosensitizers have been approved for marketing or are in clinical research. The development of photodynamic therapy in China has been very extensive.